C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/52 (2006.01) A61K 31/341 (2006.01) A61K 31/40 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2657051
Disclosed are novel cyclobutenedione Compounds comprising a cycloclobutenedione ring, a substituted phenyl ring, and a -CH(C2H5)-furan moiety. The phenyl ring and the -CH(C2H5)-furan moiety are each bound to the cyclobutenedione ring through a -NH- moiety. Also disclosed are uses o Compounds for the manufacture of a medicament for treating chemokine mediated diseases (e.g., cancer, COPD, acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, and asthma).
La présente invention concerne de nouveaux composés de cyclobutène-dione comportant un cycle cyclobutène-dione, un cycle phényle substitué et une fraction -CH(C2H5)-furane. Le cycle phényle et la fraction -CH(C2H5)-furane sont chacun liés au cycle cyclobutène-dione par une fraction -NH-. Cette invention concerne également des utilisations de composés pour produire un médicament permettant de traiter des maladies dont la médiation est assurée par des chimiokines (par ex. le cancer, les BPCO, les troubles inflammatoires aigus et chroniques, le psoriasis, la mucoviscidose et l'asthme).
Chao Jianhua
Czarniecki Michael F.
He Zhenmin
Lai Gaifa
Merritt James Robert
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Pharmacopeia Inc.
Schering Corporation
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