Sodium ion-driven chloride/bi-carbonate exchanger

Details Sodium ion-driven chloride/bi-carbonate exchanger Sodium ion-driven chloride/bi-carbonate exchanger

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/16 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2354726

The present invention discloses DNAs comprising nucleotide sequences set forth as SEQ ID NO:1 or NO:3 encoding Na+-driven Cl-/HCO3- exchanger, proteins comprising amino acid sequences set forth as SEQ ID NO:2 or NO:4, and their homologous proteins comprising an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, functions as Na+-driven Cl-/HCO3- exchanger, and cells in which the proteins exogenously expressed.

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