Novel 4-dedimethylaminotetracycline derivatives

Details Novel 4-dedimethylaminotetracycline derivatives Novel 4-dedimethylaminotetracycline derivatives

C - Chemistry, Metallurgy

07

C

C07C 237/26 (2006.01) A61K 31/65 (2006.01)

Patent

CA 2351703

The present invention provides new chemically modified 4- dedimethylaminotetracycline compounds that can be substituted at the 7,8, and/or 9 positions and methods for preparing the 4-dedimethylamino tetracycline compounds. Other tetracycline compounds are the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N-NH-Alkyl group at the C4 position. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified 4-dedimethylamino tetracycline compounds.

L'invention concerne de nouveaux composés chimiquement modifiés de 4-dédiméthylaminotétracycline pouvant être substitués au niveau des positions 7,8 et/ou 9, ainsi que des procédés servant à préparer ces composés de 4-dédiméthylaminotétracycline. D'autres composés de tétracycline sont les dérivés de 4-dédiméthylaminotétracycline comportant un groupe oxime, NH-Alkyle ou N-NH-Alkyle en position C4. Elle concerne également un procédé servant à traiter un mammifère atteint de troubles ou de maladies par administration à ce mammifère d'une quantité efficace de ces nouveaux composés chimiquement modifiés de 4-dédiméthylaminotétracycline.

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