New thiopyranopyrrole derivatives; process for preparing the...

Details New thiopyranopyrrole derivatives; process for preparing the... New thiopyranopyrrole derivatives; process for preparing the...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/395 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2109296

2109296 9220685 Nouveaux dérivés de thiopyranopyrrole de formule générale (I) dans laquelle X est un atome d'oxygène ou un radical NH, R1 est phényle éventuellement substitué, cyclohexadiényle, naphtyle, ou hétérocyclyle, R2 est H, halogène, OH, alcoyle, aminoalcoyle, alcoylaminoalcoyle, dialcoylaminoalcoyle, alcoyloxy, alcoylthio, acyloxy, carboxy, alcoyloxycarbonyle éventuellement substitué, benzyloxycarbonyle, amino ou acylamino, et n est 0, 1 ou 2, sous leurs formes stéréoisomères et leurs mélanges, éventuellement leurs sels lorsqu'ils existent et leur préparation. Les nouveaux dérivés selon l'invention sont particulièrement intéressants comme antagonistes de la substance P.

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