Tumor necrosis factor receptors 6.alpha. and 6.beta.

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2277925

The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-.alpha. and -6.beta. proteins. TNFR-6.alpha. and -6.beta. polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6.alpha. and -6.beta. activity. Also provided are diagnostic methods for detecting immune system- related disorders and therapeutic methods for treating immune system-related disorders.

La présente invention concerne de nouvelles protéines du récepteur du facteur de nécrose tumorale (TNFR). Plus particulièrement, l'invention concerne des molécules isolées d'acide nucléique codant les protéines humaines des TNFR-6.alpha. et -6.beta.. L'invention concerne aussi des polypeptides des TNFR-6.alpha. et -6.beta., des vecteurs, des cellules hôtes, et des méthodes de recombinaison pour les produire. Elle concerne enfin des méthodes de sélection permettant d'identifier des agonistes et des antagonistes de l'activité des TNFR-6.alpha. et -6.beta., ainsi que des méthodes diagnostiques pour dépister des troubles associés au système immunitaire et des méthodes thérapeutiques permettant de traiter lesdits troubles.

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