A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61K 31/4174 (2006.01) A61K 31/444 (2006.01) A61K 31/57 (2006.01) A61P 1/16 (2006.01) G01N 33/50 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2461357
Provided are methods of inhibiting proliferation and/or trans-differentiation of hepatic stellate cells, which method comprises the step of contacting hepatic stellate cells with a ligand of the low affinity glucocorticoid binding site (LAGS), which may be the rat p28 receptor or the human hpr6.6 receptor. The invention also provides ligands for use in such methods (e.g. pregnenolone 16-alpha carbonitrile) and methods for screening for the same (e.g. based on competition or displacement assays using LAGS ligands such as dexamethasone). Such ligands may be used in the treatment of liver disorders.
L'invention concerne des procédés d'inhibition de la prolifération et/ou transdifférenciation de cellules hépatiques de Kupffer, consistant à mettre en contact les cellules hépatiques de Kupffer avec un ligand du site de liaison aux glucocorticoïdes à faible affinité (LAGS), qui peut être le récepteur p28 murin ou le récepteur hpr6,6 humain. Par ailleurs, l'invention concerne des ligands utilisés dans ces procédés (par exemple, 16-alpha carbonitrile de prégnenolone) ainsi que des procédés de criblage (basés par exemple sur des dosages par compétition ou déplacement faisant intervenir les ligands LAGS, notamment la dexaméthasone). On peut utiliser ces ligands pour traiter les troubles hépatiques.
Gowling Lafleur Henderson Llp
The University Court Of The University Of Aberdeen
LandOfFree
Method for inhibiting the proliferation of hepatic stellate... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for inhibiting the proliferation of hepatic stellate..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting the proliferation of hepatic stellate... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1656233