C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01)
Patent
CA 2662005
Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FR.alpha.), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences : - RASESVSFLGINLIH (SEQ ID NO: 3), - QASNKDT (SEQ ID NO: 4), - LQSKNFPPYT (SEQ ID NO: 5), and wherein the constant region of said light chain is a kappa constant region.
L'invention concerne un anticorps ou un fragment de celui-ci, qui se lie de manière spécifique au récepteur-alpha du folate (FR.alpha.), ledit anticorps ou fragment de celui-ci comprenant une chaîne légère dont la région variable comprend au moins l'une des séquences d'acides aminés suivantes : - RASESVSFLGINLIH (SEQ ID NO : 3), - QASNKDT (SEQ ID NO : 4), - LQSKNFPPYT (SEQ ID NO : 5), et la région constante de ladite chaîne légère étant une région constante kappa.
Canevari Silvana
Cattozzo Margherita
Di Cioccio Vito
Figini Mariangela
Martin Franck
Dompe Pha.r.ma S.p.a.
Dompe S.p.a.
Istituto Nazionale Per Lo Studio E. La Cura Dei Tumori
Kirby Eades Gale Baker
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