Phosphorus-32 labeling of antibodies for cancer therapy

Details Phosphorus-32 labeling of antibodies for cancer therapy Phosphorus-32 labeling of antibodies for cancer therapy

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 51/08 (2006.01) C07K 1/13 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/54 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2200088

Recombinant fusion proteins containing at least one domain which confers targeting properties on the fusion protein, together with at least one peptide sequence that is a substrate for a protein kinase, can be labeled with 32P or 33P by treatment with a protein kinase and a 32P- or 33P-labeled phosphate donor. The labeled targeting proteins bind specifically to diseased cells or tissue, which are killed by the radiation from the 32P or 33P.

Protéines de fusion par recombinaison présentant au moins un domaine qui confère des propriétés de ciblage à la protéine de fusion, ainsi qu'au moins une séquence peptidique qui constitue un substrat pour la protéine-kinase, et pouvant être marquées à l'aide d'un ?32¿P ou d'un ?33¿P par traitement à l'aide d'une protéine-kinase et d'un donneur phosphate marqué au ?32¿P- ou ?33¿P-. Ces protéines de ciblage marquées se lient de manière spécifique à des cellules ou des tissus malades, qui sont tués par irradiation de ?32¿P ou de ?33¿P.

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