A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/545 (2006.01) A61K 31/00 (2006.01) A61K 31/12 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) A61K 31/546 (2006.01) A61K 45/00 (2006.01)
Patent
CA 2225668
Invented is a method of treating allergic reactions in a subject which comprises administering to the subject a therapectically effective amount of a compound which binds to a human Stat 6 SH2 domain with a binding affinity greater than fifty-fold higher than the binding affinity with which the compound binds to a human Stat 5 SH2 domain, binds to a human hcp SH2 domain, a human Grb2 SH2 domain, a human SH-PTP2 SH2 domain and a human p85 SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such Stat 6 SH2 domain, and binds to a human src SH2 domain, a human lck SH2 domain and a human fyn SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such Stat 6 SH2 domain.
L'invention porte sur une méthode de traitement de réactions allergiques chez un sujet consistant à lui administrer une quantité à effet thérapeutique d'un composé qui se fixe au domaine humain Stat 6 SH2 avec une affinité plus de 50 fois supérieure à celle avec laquelle il se fixe au domaine humain Stat 5 SH2, et une affinité plus de 50 fois inférieure à celle avec laquelle il se fixe aux domaines humains hcp SH2, Grb2 SH2, SH-PTP2 SH2 et p85 SH2, et qui se fixe aux domaines humains src SH2, lck SH2 et fyn SH2 avec une affinité plus de 50 fois inférieure à celle avec laquelle il se fixe au domaine Stat 6 SH2.
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
LandOfFree
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