C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/40 (2006.01) C07F 9/547 (2006.01)
Patent
CA 2120139
There are disclosed novel compounds of formula (I) wherein, X is -CH2-, -CHF-, -CF2, -CHOH- or -C(O)-; R6 is hy- drogen, benzyl, pentafluorophenyl, nitrophenyl, 1-benzotriazolyl or 1-succinimidoyl; Fmoc is 9-fluorenylmethyloxycarbo- nyl; and * indicates a chiral carbon atom. The Formula (I) compounds are useful in synthesizing peptides. There are also disclosed novel synthesis methods which include the step of hydrogenating a compound of formula (III) wherein R4 and R5 are C1-8 lower alkyl, to give a compound of formula (II) wherein R4 and R5 are as defined above. The compounds of formu- la (II) are useful as intermediates in preparing certain formula (I) compounds.
Burke Terrence R. Jr.
Lim Benjamin B.
Government Of The United States Of America As Represented By The
Swabey Ogilvy Renault
LandOfFree
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