Multimerized dbh enhancer domains

Details Multimerized dbh enhancer domains Multimerized dbh enhancer domains

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 19/00 (2006.01) C07H 21/02 (2006.01) C12N 1/20 (2006.01) C12N 9/02 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2386289

The invention features an enhancer cassette having the formula [X-Y]n, wherein each X is independently a noradrenergic cell-specific enhancer derived from a DBH gene; Y is absent or is a mono or polynucleotide that has between one and thirty nucleotides; and n is an integer between three and twenty, inclusive.

L'invention concerne une cassette activatrice de formule [X-Y]¿n?, dans laquelle X représente indépendamment un activateur spécifique aux cellules noradrénergiques dérivé d'un gène DBH, Y est absent ou représente un mono ou un polynucléotide qui comporte entre un et trente nucléotides, et n est un nombre entier compris entre trois et vingt inclus.

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