C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61M 1/36 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2419983
The cellular response to ultraviolet radiation exposure has been characterized on the molecular level through the use of high density gene array technology. Nucleic acid molecules and protein molecules, the expression of which are repressed or induced in response to ultraviolet radiation exposure, are identified according to a temporal pattern of altered expression post ultraviolet radiation exposure. Methods are disclosed that utilized these ultraviolet radiation-regulated molecules as markers for ultraviolet radiation exposure. Other screening methods of the invention are designed for the idenfication of compounds that modulate the response of a cell to ultraviolet radiation exposure. The invention also provides compositions useful for drug screening or pharmaceutical purposes.
L'invention concerne la réponse cellulaire à l'exposition aux rayons ultraviolets caractérisée au niveau moléculaire par l'utilisation d'une technologie d'ensembles de gènes à haute densité. Des molécules d'acide nucléique et des molécules de protéine, dont l'expression est réprimée ou induite en réponse à une exposition aux rayons ultraviolets, sont identifiées selon un type temporel d'expression modifiée post-exposition aux rayons ultraviolets. L'invention concerne des méthodes ayant utilisé ces molécules régulées par rayons ultraviolets en tant que marqueurs d'exposition aux rayons ultraviolets. D'autres méthodes de criblage de l'invention sont conçues pour l'identification de composés modulant la réaction d'une cellule à l'exposition aux rayons ultraviolets. L'invention concerne en outre des compositions utiles pour le criblage de médicaments ou à des fins pharmaceutiques.
Mbm Intellectual Property Law Llp
New York University
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