C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/62 (2006.01) A61K 31/365 (2006.01) C07D 405/06 (2006.01)
Patent
CA 2190468
The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well as in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.
L'invention a pour objet la synthèse d'acides 4-alcényl- ou 4-alcanyl-hydroxytétroniques optiquement purs à partir d'un aldéhyde optiquement pur. L'invention se rapporte en outre à l'utilisation de ces composés optiquement purs comme anti-agrégants plaquettaires puissants, agissant au niveau de la cyclooxygénase, ce qui les rend utiles pour le traitement des coronaropathies, en particulier de l'athérosclérose et, par ailleurs, comme inhibiteurs de diverses cytokines inflammatoires, ce qui les rend utiles pour le traitement des inflammations aiguës aussi bien que chroniques, ainsi que pour celui de la cachexie, de la polyarthrite rhumatoïde, de la sclérose en plaques, de la maladie de Crohn et de la rectocolite hémorragique. L'invention concerne en outre des compositions pharmaceutiques contenant les composés décrits.
Mantri Padmaja
Witiak Donald T.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ohio State University Research Foundation
LandOfFree
Synthesis of optically pure 4-alkenyl- or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of optically pure 4-alkenyl- or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of optically pure 4-alkenyl- or... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1657144