Peptides and pharmaceutical compositions having glycoprotein...

Details Peptides and pharmaceutical compositions having glycoprotein... Peptides and pharmaceutical compositions having glycoprotein...

C - Chemistry, Metallurgy

07

K

C07K 14/59 (2006.01) A61K 38/04 (2006.01) A61K 38/24 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 16/26 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2088162

2088162 9202542 PCTABS00010 A peptide having a glycoprotein hormone (ant)agonistic activity, comprising at least 2 partial peptides selected from (1) a partial peptide having an amino acid sequence comprising TDSDS based on the amino acids (92, 88, 89, 90 and 91) of the .beta.-chain of the glycoprotein hormone hFSH or a corresponding sequence of another glycoprotein hormone and/or another animal species, (2) a partial peptide having an amino acid sequence occurring in the .alpha.-chain of glycoprotein hormones and comprising SRAY, (3) a partial peptide having an amino acid sequence comprising TRDL based on the amino acids (34-37) of the .beta.-chain of the glycoprotein hormone hFSH or a corresponding sequence of another glycoprotein hormone and/or another animal species, and (4) a partial peptide having an amino acid sequence comprising AHASTA, derived from the amino acids (82 - 87) of the .alpha.-chain of the human glycoprotein hormones by replacing the cysteines by alanines, or a corresponding sequence of a glycoprotein hormone of another animal species, which partial peptides can be linked together by bridge groups, and variants and derivatives having a glycoprotein hormone agonistic or antagonistic activity.

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