Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid...

Details Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid... Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid...

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01)

Patent

CA 2560314

2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11&bgr;-hydroxysteroid dehydrogenase Type 1 enzyme (11&bgr;- HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity, insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11&bgr;-HSD-1.

L'invention concerne des dérivés 2,5-diaryl-1,2,4-triazole représentés par la formule générale (I) qui sont des inhibiteurs sélectifs de l'enzyme 11.beta.-hydroxystéroïde déshydrogénase de type 1 (11.beta.-HSD-1). Ces composés sont utiles pour le traitement du diabète, de l'hyperglycémie, de l'obésité, de la résistance à l'insuline, de l'athérosclérose, de la dyslipidémie, de l'hyperlipidémie, de l'hypertension et du syndrome métabolique. L'invention concerne également de nouveaux composés représentés par la formule générale (II) qui sont des inhibiteurs de 11.beta.-HSD-1.

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