Detection of certain molecules

Details Detection of certain molecules Detection of certain molecules

C - Chemistry, Metallurgy

12

N

167/37, 195/1.2,

C12N 15/11 (2006.01) C07K 14/545 (2006.01) C12N 5/10 (2006.01) C12N 15/65 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2011799

ABSTRACT Detection of Certain Molecules A mammalian cell line having an inheritable genetic element comprising a TNF, IL-1.alpha. or IL-1.beta. promoter and, under transcriptional control thereof, a coding region, wherein the promoter controls transcription of the coding region in response to the exposure of the said cell line to a pyrogen and the said coding region encodes a reporter polypeptide The cell line is used as the basis of an assay. The promoter is preferably the human interleukin-1.alpha. or -1.beta. promoter, the cell line is preferably human monocyte derived, and the reporter polypeptide may be .beta.-galactosidase, .alpha.-galactosidase, chloramphenicol acetyl transferase, luciferase or phosphatase.

Affiliated with

Also associated with

Rating

Detection of certain molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Detection of certain molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of certain molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1658492