C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/80 (2006.01) A61K 31/343 (2006.01) A61P 9/06 (2006.01) C07D 209/18 (2006.01) C07D 307/00 (2006.01) C07D 333/60 (2006.01)
Patent
CA 2425245
The subject invention pertains to novel compounds, and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns a method of making the novel compounds. The novel compounds are rapidly metabolized analogs of amiodarone, having the distinct and advantageous characteristic of being metabolized to a less lipophilic compound. The new compounds can have particular utility for treating life- threatening ventricular tachyarrhythmias, especially in patients with congestive heart failure (CHF). The product can also provide effective management for ventricular arrhythmias and supraventricular arrhythmias, including atrial fibrillation and re-entrant tachyarrhythmias involving accessory pathways.
L'invention concerne des nouveaux composés et des compositions renfermant ces composés destinés au traitement d'arythmies cardiaques. L'invention concerne en outre un procédé de préparation des nouveaux composés qui sont des analogues rapidement métabolisés d'amiodarone présentant la caractéristique distincte et avantageuse d'être métabolisés en un composé moins lipophile. Les nouveaux composés présentent une utilité particulière dans le traitement de tachyarythmies ventriculaires constituant un danger de mort, notamment chez des patients souffrant d'insuffisance cardiaque congestive (CHF). Le produit permet de gérer de manière efficace des arythmies ventriculaires et supraventriculaires, notamment une fibrillation auriculaire et des tachyarythmies réentrantes mettant en oeuvre des voies auxiliaires.
Druzgala Pascal
Milner Peter G.
Aryx Therapeutics
Mbm Intellectual Property Law Llp
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