Use of c-kit inhibitors for treating inflammatory muscle...

Details Use of c-kit inhibitors for treating inflammatory muscle... Use of c-kit inhibitors for treating inflammatory muscle...

A - Human Necessities

61

K

A61K 31/426 (2006.01) A61K 31/421 (2006.01) A61K 31/506 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2564568

The present invention relates to a method for treating inflammatory muscle disorders including myositis and muscular dystrophy comprising administering a compound capable of depleting mast cells or a compound inhibiting mast cell degranulation, to a human in need of such treatment. Such compounds can be chosen from c-kit inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

L'invention concerne un procédé permettant de traiter des troubles musculaires inflammatoires, notamment la myosite et la dystrophie musculaire, qui consiste à administrer à un humain nécessitant un tel traitement un composé pouvant affaiblir des mastocytes ou un composé inhibant la dégranulation de mastocytes. Ces composés peuvent être choisis parmi des inhibiteurs de c-kit, plus précisément, des inhibiteurs de c-kit puissants, sélectifs et non toxiques. De préférence, ledit inhibiteur est incapable de favoriser la mort de cellules dépendantes de IL-3 cultivées en présence de IL-3.

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