Topical composition and method for enhancing lipid barrier...

A - Human Necessities – 61 – K

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A61K 8/49 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2266048

The present invention relates to topical com-positions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol or kahweol, or derivative thereof, in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged. Figure 5 shows increased ceramide synthesis with cafestol.

Cette invention se rapporte à des compositions topiques servant à améliorer la synthèse des lipides dans la peau, de telles compositions comprenant une quantité efficace de cafestol ou de kahweol, ou d'un dérivé de ceux-ci, en association avec un excipient acceptable sur le plan pharmaceutique ou cosmétique. Ces compositions sont utiles pour traiter ou prévenir la peau sèche et les conditions dans lesquelles la barrière lipidique de la peau est défectueuse ou endommagée. La figure 5 illustre une synthèse améliorée du céramide avec du cafestol.

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