C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 267/20 (2006.01) A61K 31/55 (2006.01) C07D 223/20 (2006.01) C07D 233/20 (2006.01) C07D 243/38 (2006.01) C07D 281/16 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01)
Patent
CA 2051830
The invention relates to tricyclic heterocycles, or pharmaceutically-acceptable salts thereof, which possess anti-hyperalgesic properties. The invention also relates to processes for the manufacture of said tricyclic heterocycles; and to novel pharmaceutical compositions containing them. The invention provides a tricyclic heterocycle of the formula I (see formula I) wherein X is oxy, thio, sulphinyl, sulphonyl, amino, (1-4C)alkylamino or methylene; Y is carbonyl or methylene; each R1 includes hydrogen and halogeno; each of m and n is 1 or 2; each of A1 and A2 is a direct link, alkylene, alkenylene or alkynylene; Ar is phenylene which may optionally bear one or two substituents; and G is carboxy, 1H-tetrazol-5-yl or a group of the formula:- -CONH-SO2R2 wherein R2 is (1-4C)alkyl, benzyl or phenyl; or a pharmaceutically-acceptable salt thereof.
Imperial Chemical Industries Plc
Smart & Biggar
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