Packaging cell lines for use in facilitating the development...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/34 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2266342

The present invention relates to gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel packaging cell lines are disclosed, for use in facilitating the development of high-capacity vectors. The invention also discloses a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, the invention discloses methods of preparing and using the disclosed vectors, cell lines and kits.

La présente invention concerne la thérapie génique, et plus particulièrement, la thérapie génique à base d'adénovirus ainsi que des lignées cellulaires et des compositions apparentées. En particulier, l'invention traite de nouvelles lignées cellulaires d'enroulement pour faciliter le développement de vecteurs à grande capacité. L'invention traite aussi de divers vecteurs d'adénovirus à grande capacité, et de compositions et d'ensembles apparentés comprenant les lignées cellulaires et les vecteurs de l'invention. Enfin, l'invention a aussi pour objet des procédés de préparation et d'utilisation des vecteurs, des lignées cellulaires et des ensembles décrits.

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