C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/08 (2006.01) A61B 8/13 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/22 (2006.01)
Patent
CA 2218541
Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein or a polymer and a gas, in combination with a targeting ligand. The targeting ligand targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.
Ces nouvelles compositions ciblées, que l'on peut utiliser à des fins diagnostiques et thérapeutiques, peuvent comprendre un lipide, une protéine ou un polymère, ainsi qu'un gaz, en combinaison avec un ligand de ciblage. Ce ligand cible des tissus, des cellules ou des récepteurs, notamment des cellules myocardiques, endothéliales, épithéliales, tumorales, ainsi que le récepteur de la glycoprotéine GPIIbIIIa. On peut utiliser ces substances de contraste conjointement avec l'imagerie diagnostique, telle que l'échographie, ainsi qu'avec des applications thérapeutiques, telles que l'ultrasonothérapie.
Shen Dekang
Unger Evan C.
Wu Guanli
Imarx Pharmaceutical Corp.
Smart & Biggar
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