Reducing the immunogenicity of fusion proteins

Details Reducing the immunogenicity of fusion proteins Reducing the immunogenicity of fusion proteins

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) A61K 38/24 (2006.01) A61K 38/27 (2006.01) A61K 45/00 (2006.01) A61K 47/00 (2006.01) C07K 14/00 (2006.01) C07K 14/505 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2442363

Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T- cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T-cell receptor. Compositions and methods of the invention are useful in therapy.

Cette invention concerne des compositions et méthodes permettant d'obtenir des protéines à antigénicité réduite. Les protéines de fusion selon l'invention comprennent une région de jonction avec changement d'acides aminés qui réduit la capacité de l'épitope de jonction de se lier à un MHC de classe II, ce qui atténue son interaction avec un récepteur de lymphocyte T. Les méthodes selon l'invention consistent à analyser, remplacer ou modifier un ou plusieurs acides aminés dans la région de jonction d'une protéine de fusion afin d'identifier un épitote de lymphocyte T et de réduire son aptitude à interagir avec un récepteur de lymphocyte T. Les compositions et les méthodes selon cette invention présentent des applications thérapeutiques.

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