A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/353 (2006.01) A61P 1/08 (2006.01) A61P 3/00 (2006.01) A61P 29/00 (2006.01) C07D 311/80 (2006.01)
Patent
CA 2587957
Methods for making trans-(-)-.DELTA.9-tetrahydrocannabinoI and trans-(+)- .DELTA.9-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans- (-)-.DELTA.9-tetrahydrocannabinoI composition is prepared by allowing a composition comprising (~)-.DELTA.9-tetrahydrocannabinol to separate on a chiral stationary phase to provide a trans-(-)-.DELTA.9-tetrahydrocannabinoI composition comprising at least about 99% by weight of trans-(-)-.DELTA.9- tetrahydrocannabinol based on the total amount of trans-(-)-.DELTA.9- tetrahydrocannabinol and trans-(+)-.DELTA.9-tetrahydrocannabinol. The invention also relates to methods for treating or preventing a condition such as pain comprising administering to a patient in need thereof an effective amount of a trans-(-)-.DELTA.9-tetrahydrocannabinoI having a purity of at least about 98% based on the total weight of cannabinoids.
L'invention porte sur des procédés de fabrication de trans-(-)-.DELTA.9-tetrahydrocannabinoI et trans-(+)-.DELTA.9-tetrahydrocannabinol. Dans un mode de réalisation, une composition de trans-(-)-.DELTA.9-tetrahydrocannabinoI est préparée grâce à la séparation d'une composition contenant (±)-.DELTA.9-tetrahydrocannabinol sur une phase fixe afin d'obtenir une composition de trans-(-)-.DELTA.9-tetrahydrocannabinoI contenant au moins 99 % environ en poids de trans-(-)-.DELTA.9-tetrahydrocannabinol en fonction de la quantité totale de trans-(-)-.DELTA.9-tetrahydrocannabinol et de trans-(+)-.DELTA.9-tetrahydrocannabinol. Cette invention concerne aussi des procédés de traitement ou de prévention d'une condition telle une douleur consistant à administrer à un patient qui en a besoin une quantité efficace de trans-(-)-.DELTA.9-tetrahydrocannabinoI possédant un niveau de pureté d'au moins 98 % environ en fonction du poids de cannabinoïdes.
Etinger Marina
Fedotev Irina
Gutman Arie L.
Khanolkar Ram
Nisnevich Gennady A.
Euro-Celtique S.a.
Gowling Lafleur Henderson Llp
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