Pharmaceutical combination composition comprising at least...

Details Pharmaceutical combination composition comprising at least... Pharmaceutical combination composition comprising at least...

A - Human Necessities

61

K

A61K 31/404 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 45/06 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2644207

The present invention relates to a pharmaceutical combination comprising at least one PKC inhibitor, in particular indolylmaleimide derivatives, and at least one JAK3 kinase inhibitor and the uses of such a combination e.g. in autoimmune diseases, e.g. in preventing or treating type I diabetes mellitus and disorders associated therewith, or in transplantation.

La présente invention concerne une combinaison pharmaceutique contenant au moins un inhibiteur de la protéine kinase C (PKC), en particulier des dérivés indolylmaléimide, et au moins un inhibiteur de la JAK-3 kinase, et les utilisations d'une telle combinaison, notamment dans les maladies auto-immunes, dans la prévention ou le traitement du diabète sucré de type I et dans les troubles qui y sont associés, ou dans les transplantations.

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