Compounds for treatment of cancer

Details Compounds for treatment of cancer Compounds for treatment of cancer

C - Chemistry, Metallurgy

07

D

C07D 277/24 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01) C07D 233/22 (2006.01) C07D 263/34 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2728118

Compounds according to formula (I) are disclosed, (I), where Q is S, N, or O; X is optional, and can be O=, S=, =N-NH2, =N-- OH, or -OH; Y is optional and can be -N(H)-, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.

Cette invention concerne des composés de formule (I), (I), Q étant S, N ou O; X étant facultatif et pouvant être O=, S=, =N-NH2, =N-OH, ou -OH; Y étant facultatif et pouvant être -N(H)-, O, ou un hydrocarbure en C1 à C20 ; et R1 et R2 étant chacun indépendamment un système substitué ou non de cycles (hétéro)cycliques ou aryle à cycle simple, fusionné ou multiple. L'invention décrit également des procédés de préparation de ces composés, des compositions pharmaceutiques les contenant, et leur utilisation, en particulier, pour traiter ou prévenir le cancer.

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