Human sodium-dependent phosphate cotransporter

Details Human sodium-dependent phosphate cotransporter Human sodium-dependent phosphate cotransporter

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2281669

The present invention provides a human sodium-dependent phosphate cotransporter (NAPTR) and polynucleotides which identify and encode NAPTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NAPTR and a method for producing NAPTR. The invention also provides for agonists, antibodies, or antagonists specifically for NAPTR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NAPTR for the treatment of diseases associated with the expression of NAPTR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NAPTR. The invention also provides a method for treating disorders associated with decreased phosphate levels by administering NAPTR and a method for treating disorders associated with increased phosphate levels by administering antagonists to NAPTR.

La présente invention concerne un cotransporteur de phosphate humain dépendant du sodium (NAPTR) et des polynucléotides identifiant et codant pour NAPTR. L'invention se réfère également à des vecteurs et à des cellules hôte mis au point génétiquement, qui contiennent les séquences d'acides nucléiques codant pour NAPTR, et à un procédé de production de NAPTR. L'invention concerne également des agonistes, des anticorps, et des antagonistes spécifiques de NAPTR. De plus, l'invention concerne l'utilisation de molécules antisens de polynucléotides codant pour NAPTR en vue du traitement de maladies associées à l'expression de NAPTR. L'invention concerne également des méthodes diagnostiques employant le polynucléotide, des fragments ou le complément de celui-ci, et des anticorps se liant spécifiquement à NAPTR. L'invention concerne également un procédé permettant de traiter des troubles associés à des taux élevés de phosphate, par l'administration d'antagonistes de NAPTR.

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