.beta.,.beta.'-dihydroxy meso-substituted chlorins,...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/22 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) C07F 3/06 (2006.01) C07F 5/00 (2006.01) C07F 7/00 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2199399

Image A .beta.,.beta.'-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compound having formula (I) or (II), wherein M is a metal. A novel method for synthesizing the compound of formula (I) or (II) comprises the steps of: a) osmylating a J.J'-unsubstituted, meso-substituted porphyrin to form an osmate ester at the ,O,Q'-position; and b) reducing the osmate ester to form the corresponding .beta.,.beta.'- dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin of formula (I) or (II).

L'invention se rapporte à un composé de chlorine, bactériochlorine ou isobactériochlorine beta , beta '-dihydroxy méso-substitué ayant la formule (I) ou (II) dans laquelle M représente un métal. Un nouveau procédé de synthèse du composé de la formule (I) ou (II) consiste à: a) osmyler une porphyrine J.J'-non substituée, méso-substituée pour obtenir un ester d'osmate en position beta , beta ', et b) réduire l'ester d'osmate pour obtenir la chlorine, bactériochlorine ou isobactériochlorine beta , beta '-dihydroxy méso-substituée correspondante de la formule (I) ou (II).

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