Pharmaceutical conjugates with enhanced pharmacokinetic...

Details Pharmaceutical conjugates with enhanced pharmacokinetic... Pharmaceutical conjugates with enhanced pharmacokinetic...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2471589

Pharmaceutical conjugates comprising a therapeutic component and an efficacy enhancing component that enhances the pharmacokinetic disposition of the therapeutic component is disclosed. In one embodiment, therapeutic component is joined to an efficacy enhancing component by a linker. In one embodiment, the therapeutic component and the efficacy enhancing component disassociate under physiolocal conditions, preferably near the site where the therapeutic component may exert a therapeutic effect.

L'invention concerne des conjugués pharmaceutiques qui comprennent un composant thérapeutique et un composant d'amélioration de l'efficacité servant à améliorer la disposition pharmacocinétique du composant thérapeutique. Dans un mode de réalisation, le composant thérapeutique est relié au composant d'amélioration de l'efficacité par un lieur. Dans un autre mode de réalisation, le composant thérapeutique et le composant d'amélioration de l'efficacité se séparent dans des conditions physiologiques, de préférence à proximité du site où le composant thérapeutique peut produire un effet thérapeutique.

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