Composition for prevention and treatment of hiv-1 infection...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61K 31/33 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2204652

A composition and method for the prevention or treatment of HIV-1 infection comprising an HIV-1 reverse transcriptase-inhibiting hterocyclyl carb(ox/thio)anilide compound, a second HIV-1 reverse transcriptase inhibitor compound which does not select for the same HIV--1 mutant strain or strains selected for by the heterocyclil carb(ox/thio)anilide compound, and, optionally, a thrid HIV reverse transcriptase inhibitor compound.

On décrit une composition ainsi qu'une méthode de prévention et de traitement d'une infection à VIH-1, cette composition comprenant un composé hétérocyclyle carb(ox/thio)anilide inhibant la transcriptase inverse du VIH-1, un second composé inhibant également cette transcriptase du VIH-1 mais ne choisissant pas la même ou les mêmes souche(s) mutante(s) du VIH-1 que celle(s) choisie(s) par le composé hétérocyclyle carb(ox/thio)anilide, ainsi qu'éventuellement un troisième composé inhibant la transcriptase inverse du VIH.

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