Transcription factor e2f dna-binding domain inhibitor...

Details Transcription factor e2f dna-binding domain inhibitor... Transcription factor e2f dna-binding domain inhibitor...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2359043

The present invention provides peptides which bind to the DNA binding domain of transcription factor E2F, and inhibit cell cycle progression. Peptides include FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); and GSRILTFRSGSWYAS (SEQ ID NO:5) and derivatives based upon these sequences. Compositions and the use of the peptides in inhibiting cell cycle progression, such as in uncontrolled cell proliferation, are also provided.

La présente invention concerne des peptides qui se lient au domaine liant l'ADN du facteur de transcription et inhibent la progression du cycle cellulaire. Ces peptides comprennent FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); et GSRILTFRSGSWYAS (SEQ ID NO:5) ainsi que les dérivés fondés sur ces séquences. L'invention concerne aussi des compositions et l'utilisation des peptides dans l'inhibition de la progression du cycle cellulaire.

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