Recombinant papilloma virus l1

Details Recombinant papilloma virus l1 Recombinant papilloma virus l1

C - Chemistry, Metallurgy

12

N

C12N 15/37 (2006.01) A61K 39/12 (2006.01) C07K 14/025 (2006.01) C07K 16/08 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2190473

This invention relates to a recombinant papilloma virus L1 protein which can elicit an immune response which recognises papilloma virus VLP including L1 protein and can form extracellularly a multimeric structure or VLP wherein the multimeric structure comprises a plurality of recombinant papilloma virus L1 proteins. This invention also includes the use of the recombinant papilloma virus L1 protein to detect the presence of papilloma virus and can form the basis of a vaccine for prophylactic and therapeutic use.

L'invention concerne une protéine L1 de papillomavirus recombiné pouvant provoquer une réponse immunitaire qui reconnaît une particule de type viral du papillomavirus contenant la protéine L1, et pouvant former de façon extracellulaire une structure multimère ou une particule de type viral, la structure multimère comprenant une pluralité de protéines L1 du papillomavirus recombiné. L'invention concerne également l'utilisation de la protéine L1 du papillomavirus recombiné dans le but de détecter la présence de papillomavirus. L'invention peut servir de base à un vaccin à usage prophylactique et thérapeutique.

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