Human complementarity determining region (cdr) - grafted...

Details Human complementarity determining region (cdr) - grafted... Human complementarity determining region (cdr) - grafted...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2226400

A human CDR-grafted antibody which specifically reacts with ganglioside CM2, wherein said antibody comprises CDR 1, CDR 2 and CDR 3 of heavy chain (H chain) variable region (V region) comprising amino acid sequences described in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and CDR 1, CDR 2 and CDR 3 of light chain (L chain) V region comprising amino acid sequences described in SEQ ID NO:4, SEQ ID NO: 5 and SEQ ID NO:6, and wherein at least one of the frameworks (FR) of said H chain and L chain V regions comprises an amino acid sequence selected from common sequences (HMECS; human most homologous consensus sequence) derived from human antibody subgroups.

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