Trans olefinic glucokinase activators

Details Trans olefinic glucokinase activators Trans olefinic glucokinase activators

C - Chemistry, Metallurgy

07

D

C07D 277/46 (2006.01) A61K 31/17 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61P 3/10 (2006.01) C07C 275/50 (2006.01) C07C 317/44 (2006.01) C07D 213/75 (2006.01) C07D 277/56 (2006.01)

Patent

CA 2392903

2,3-Di-substituted trans olefinic N-heteroaromatic or urido proprionamides of formula (I) with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said proprionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

Propionamides transoléfiniques 2,3-disubstitués N-hétéroaromatiques ou urido-propionamides représentés par la formule (I), ladite substitution au niveau de la position 2 représentant un groupe phényle substitué et, au niveau de la position 3, un noyau cycloalkyle, lesdits propionamides consistant en des activateurs de glucokinase augmentant la sécrétion de l'insuline dans le traitement de diabètes de type II.

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