Treating and diagnosing macrophage-mediated diseases using...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 47/48 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2321136

The invention provides methods and compositions for selectively targeting macrophages in a localized area. The compositions of the invention include an Fc receptor binding agent, and a toxic or a detectable agent. Methods for depleting or inhibiting the activity of macrophages using the compositions of the invention are disclosed. The compositions of the invention can be used therapeutically and diagnostically.

L'invention concerne des procédés et des compositions pour choisir de manière sélective des macrophages dans une zone localisée. Les compositions de cette invention comprennent un agent liant les récepteurs de Fc et un agent toxique ou détectable. L'invention concerne des procédés pour affaiblir ou freiner l'activité des macrophages au moyen des compositions ci-décrites. Les compositions de cette invention peuvent s'utiliser dans la thérapie et le diagnostic.

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