Predictive biomarkers

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2736233

A set of biomarkers have been identified that allows one to predict subjects who will respond to an exercise regime in term of cardiorespiratory fitness as assessed by maximal oxygen uptake. These predictions may be used, for example, to predict risk of cardiovascular disease, to design a more effective program for cardiac rehabilitation, to predict capacity for athletic performance or physically demanding occupation, and to predict ability to maintain functional capacity with aging using exercise.

La présente invention concerne un ensemble de biomarqueurs identifiés, qui permettent de prévoir quels sujets réagiront à un régime dexercice en termes de bonne condition cardiorespiratoire, par lévaluation dune absorption doxygène maximale. Ces prévisions peuvent être utilisées, par exemple, pour prévoir le risque de maladie cardiovasculaire, pour concevoir un programme de réadaptation cardiaque plus efficace, pour prévoir une capacité de performance athlétique ou une occupation physiquement exigeante, et pour prévoir laptitude à maintenir une capacité fonctionnelle avec le vieillissement au moyen dexercice.

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