C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 39/00 (2006.01) C07K 7/08 (2006.01) C12N 5/00 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2561376
The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of said viral protein or fragment, said polypeptide comprising the minimum following consensus amino acid sequence: X1Y9Y10Y11CY12X2 wherein, X1 and X2 are selected to impact on said immunosuppressive properties, and Y9 to Y12 represent variable amino acid residues.
L'invention concerne un polypeptide présentant une séquence de 7 à 20 résidus d'acides aminés, capable de moduler les propriétés immunosuppressives d'une protéine virale ou d'un fragment de celle-ci, contre l'hôte dans lequel elle est exprimée (séquence immunosuppression-modulatrice) lorsqu'elle remplace la séquence homologue de la protéine virale ou du fragment concernés. Ledit polypeptide comprend au minimum la séquence d'acides aminés consensuelle suivante: X¿1?Y¿9?Y¿10?Y¿11?CY¿12?X¿2?, dans laquelle X¿1? et X¿2? sont choisis de façon à avoir un impact sur lesdites propriétés immunosuppressives, et Y¿9? à Y¿12? représentent des résidus d'acides aminés variables.
Heidmann Thierry
Mangeney Marianne
Renard Martial
Centre National de La Recherche Scientifique
Goudreau Gage Dubuc
Institut Gustave Roussy
Universite Paris Sud Xi
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