Pyrazolopyrimidines as cyclin dependent kinase inhibitors

Details Pyrazolopyrimidines as cyclin dependent kinase inhibitors Pyrazolopyrimidines as cyclin dependent kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2497450

In its many embodiments, the present invention provides a novel class of pyrazolo~1,5-a~pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Dans de nombreux modes de réalisation, l'invention concerne une nouvelle classe de composés de pyrazoloÝ1,5-a¨pyrimidine utilisés en tant qu'inhibiteurs des kinases cycline-dépendantes; des procédés de préparation desdits composés; des compositions pharmaceutiques contenant un ou plusieurs desdits composés; des procédés des préparation de formulations pharmaceutiques comprenant un ou plusieurs desdits composés; et des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou de plusieurs maladies associées aux kinases cycline-dépendantes mis en oeuvre au moyen desdits composés ou desdites compositions pharmaceutiques.

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