Oral pharmaceutical extended release dosage form

Details Oral pharmaceutical extended release dosage form Oral pharmaceutical extended release dosage form

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2315261

An enteric coated pharmaceutical extended release dosage form of an H+,K+- ATPase inhibitor giving an extended plasma concentration profile of an H+,K+-ATPase inhibitor. The extended plasma profile is obtained by a pharmaceutical composition which comprises a core material of a hydrophilic or hydrophobic matrix, and the H+,K+-ATPase inhibitor and optionally pharmaceutically acceptable excipients. The dosage form may be administered once daily.

La présente invention concerne une forme posologique pharmaceutique kératinisée à libération prolongée, comportant un inhibiteur de H<+>,K<+>-ATPase produisant un profil de concentration de plasma prolongé d'un inhibiteur de H<+>,K<+>-ATPase. On obtient le profil de plasma prolongé par une composition pharmaceutique comprenant une matière de noyau d'une matrice hydrophile ou hydrophobe, ainsi que l'inhibiteur de H<+>,K<+>-ATPase et éventuellement des excipients acceptables sur le plan pharmaceutique. Cette forme posologique peut être administrée une fois par jour.

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