Pyridinyl amides for the treatment of cns and metabolic...

Details Pyridinyl amides for the treatment of cns and metabolic... Pyridinyl amides for the treatment of cns and metabolic...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61K 31/496 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2714232

The present invention relates to novel pyridinyl derivatives of Formula (I), wherein Y, Z, L, R1 through R11, n, m, p, q, t are as defined herein, that are 5-HT receptor ligands, particularly the 5-HT6 subtype, and as such are useful for treating diseases wherein modulation of 5-HT activity is desired. The present invention relates to novel pyridinyl derivatives including their pharmaceutically acceptable salts. The invention also relates to processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing and the uses of such compounds in treating diseases of the central nervous system such as schizophrenia.

La présente invention concerne de nouveaux dérivés de pyridinyle de Formule (I). Dans la Formule (I), Y, Z, L, R1 à R11, n, m, p, q, t sont tels que définis ici. Les dérivés de pyridinyle selon l'invention sont des ligands du récepteur 5-HT, en particulier, du sous-type 5-HT6, et à ce titre, ils sont utiles pour traiter les maladies où une modulation de l'activité 5-HT est souhaitée. La présente invention concerne de nouveaux dérivés de pyridinyle comprenant leurs sels pharmaceutiquement acceptables, ainsi que des procédés de préparation d'intermédiaires utilisés dans la préparation de compositions pharmaceutiques les contenant et les utilisations de ces composés pour traiter les maladies du système nerveux central telles que la schizophrénie.

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