Carboxylic acid derivatives having fused rings as retinoic...

Details Carboxylic acid derivatives having fused rings as retinoic... Carboxylic acid derivatives having fused rings as retinoic...

C - Chemistry, Metallurgy

07

D

C07D 417/00 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4439 (2006.01) C07D 207/337 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 407/04 (2006.01) C07D 409/14 (2006.01) C07D 413/00 (2006.01)

Patent

CA 2247451

The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof. (see formula I) {wherein the symbol ~ represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: -O- or -S-, or a group represented by the formula: Image [wherein R k (k : 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R7 and R8 being a group represented by the formula: Image (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

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