Novel anandamide amidase inhibitors as analgesic agents

Details Novel anandamide amidase inhibitors as analgesic agents Novel anandamide amidase inhibitors as analgesic agents

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/22 (2006.01) A61K 31/40 (2006.01) C07D 207/46 (2006.01)

Patent

CA 2615696

Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. Compounds of the invention are represented by Structural Formula (I): R-X-Y (I) wherein R is selected from the group consisting of a methyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, and an optionally substituted heterocyclic group; X is an optionally substituted straight chain hydrocarbyl group containing from 10-24 carbon atoms if R is a methyl group, and from 4-18 carbon atoms if R is an optionally substituted aryl group, an optionally substituted heteroaryl group, or an optionally substituted heterocyclic group; and Y is a moiety capable of irreversibly binding to a nucleophilic group at the active site of an amidase enzyme.

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