A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) C07K 14/71 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2436748
Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal. Also disclosed are methods of treating diseases in which plasma leakage and/or vascular permeability occurs, for example, inflammatory skin diseases.
La présente invention concerne des polypeptides chimériques modifiés avec des éléments pharmacocinétiques modifiés. Cette invention concerne en particulier des polypeptides de récepteur de Flt1 chimériques modifiés qui ont été modifiés de façon à améliorer leur profil pharmacocinétique. Cette invention concerne aussi des techniques de préparation et d'utilisation de polypeptides modifiés comprenant notamment l'utilisation de polypeptides modifiés pour diminuer ou inhiber les fuites de plasma et/ou la perméabilité vasculaire chez un mammifère. Cette invention concerne enfin des techniques de traitement dans lesquelles la fuite de plasma et/ou la perméabilité vasculaire apparaît, par exemple, des maladies cutanées inflammatoires.
Rudge John S.
Xia Yuping
Yancopoulos George D.
Osler Hoskin & Harcourt Llp
Regeneron Pharmaceuticals Inc.
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