Aryl sulfonamides useful for modulation of the progesterone...

Details Aryl sulfonamides useful for modulation of the progesterone... Aryl sulfonamides useful for modulation of the progesterone...

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61P 15/18 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2679564

In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Formula (I). Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; treating or preventing uterine leiomyomata; treating or preventing endometriosis, dysfunctional bleeding, and polycystic ovary syndrome; treating or preventing hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms using the compounds described herein.

Dans un mode de réalisation, la présente invention concerne des composés de la structure suivante, les R1 à R7 étant décrits ici. Formule (I) : L'invention concerne également des procédés de préparation de ces composés et des procédés de contraception; le traitement ou la prévention des fibromyomes; le traitement ou la prévention des léiomyomes utérins; le traitement ou la prévention de l'endométriose, la ménométrorragie fonctionnelle, et le syndrome des ovaires polykystiques; le traitement ou la prévention des carcinomes hormono-dépendants; la mise en AEuvre d'une thérapie hormonale de remplacement; la stimulation de la prise alimentaire; la synchronisation de l'AEstrus; et le traitement des symptômes relatifs au cycle en utilisant les composés décrits ici.

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