Solid fat nanoemulsions as drug delivery vehicles

Details Solid fat nanoemulsions as drug delivery vehicles Solid fat nanoemulsions as drug delivery vehicles

A - Human Necessities

61

K

A61K 9/10 (2006.01) A01N 1/02 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2162993

The present invention provides pharmaceutical compositions comprising nanoemulsions of particles comprising a lipid core which is in a solid or liquid crystalline phase at 25 °C, stabilized by at least one phospholipid envelope, for the parenteral, oral, intranasal, rectal, or topical delivery of both fat-soluble and water-soluble drugs. Particles have a mean diameter in the range of 10 to 250 nm. A wide variety of drugs and oxygen transporting perfluorocarbons may be encapsulated in the particles. In addition to drug delivery vehicles, the invention provides oxygen transporting blood substitutes, and nanoemulsions for extracorporeal maintenance of tissues prior to transplantation.

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