Reversible masking of liposomal complexes for targeted delivery

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2495124

The present invention is a composition and process for avoiding non-specific uptake of targeted liposomal complexes in the lung and other highly vascular tissues. The reversible masking of liposomal complexes allows increased delivery of nucleic acid molecules to target cells or tissues.

La présente invention concerne une composition et un processus permettant d'éviter la prise non spécifique de complexes liposomaux ciblés dans le poumon et dans d'autres tissus extrêmement vascularisés. Ce masquage réversible de complexes liposomaux permet une administration accrue de molécules d'acides nucléiques aux cellules ou tissus cibles.

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