Multivalent carriers of bi-specific antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2531118

Provided herein are targetable constructs that are multivalent carriers of bi- specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targetable construct with two or more bi-specific antibodies. The targetable constructs and targetable complexes of the invention are incorporated into biosensors, kits and pharmaceutical compositions, and are used in a variety of therapeutic and other methods.

L'invention concerne des constructions pouvant être ciblées qui sont des porteuses polyvalentes d'anticorps bispécifiques, c'est-à-dire, que chaque molécule d'une construction pouvant être ciblée peut servir en tant que porteuse d'au moins deux anticorps bispécifiques. L'invention concerne également des complexes pouvant être ciblés formés par l'association d'une construction pouvant être ciblée avec au moins deux anticorps bispécifiques. Les constructions pouvant être ciblées et les complexes pouvant être ciblés de l'invention sont incorporés dans des biodétecteurs, des kits et des compositions pharmaceutiques, et ils sont utilisés dans une pluralité de procédés thérapeutiques et d'autres procédés.

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