Quinoline derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 215/12 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2505873

The present invention relates to compounds of Formula I, wherein R1, R2, R3, R4, and n are as defined, and to pharmaceutically acceptable salts of said compounds. Compounds of Formula I have activity in agonizing 5HT7 receptors and are useful in treating, for example, disorders that can be treated by modulating circadian rhythms.

La présente invention concerne, d'une part des composés représentés par la formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et n sont tels que décrits dans les spécifications, et d'autre part des sels pharmaceutiquement admis de ces composés. Les composés représentés par la formule (I), qui font preuve d'une activité d'agoniste par rapport aux récepteurs 5HT7, s'adressent particulièrement au traitement de troubles pouvant se traiter par une modulation des rythmes circadiens.

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