Dye-bioconjugates for simultaneous optical diagnostic and...

Details Dye-bioconjugates for simultaneous optical diagnostic and... Dye-bioconjugates for simultaneous optical diagnostic and...

A - Human Necessities

61

B

A61B 5/00 (2006.01) A61B 8/00 (2006.01) A61B 10/00 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2474920

Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.

L'invention concerne des nouveaux agents photothérapeutiques et photodiagnostiques spécifiques de tumeur. Ces composés sont constitués d'un colorant carbocyanine permettant d'assurer la visualisation, d'un photosensibilisant permettant d'assurer un traitement photodynamique, et d'un peptide attiré par les récepteurs tumoraux permettant d'assurer une administration, spécifique de site, de sonde et d'agent phototoxique à des tissus pathologiques. Une combinaison de ces éléments possède l'avantage de présenter des propriétés uniques et efficaces, propres à chaque composant, afin d'assurer une gestion efficace de la prise en charge des patients.

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