Novel therapeutic targets in cancer

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2510311

The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

La présente invention concerne des nouvelles séquences utilisées pour la détection, le diagnostic et le traitement des cancers, en particulier des lymphomes. L'invention porte sur des séquences de polynucléotides associées au cancer (CA) dont l'expression est associée au cancer. La présente invention concerne des polypeptides CA qui sont présents sur la surface de la cellule et qui constituent de nouvelles cibles thérapeutiques contre le cancer. Elle concerne également des compositions et des méthodes diagnostic pour la détection du cancer. La présente invention concerne des anticorps monoclonaux et polyclonaux spécifiques des polypeptides CA. Elle concerne en outre des outils de diagnostic et des compositions thérapeutiques pour le criblage, la prévention et le traitement du cancer.

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